Figure 1

Needle customization and paraffin block punching. Needle customization, step by step – cutting the tip (A1 to A3), opening the lateral window (A4 to B2), creating a new bevel (B3 to C1) and custom-built needles (C2); TMA production kit (C3); paper grids (C4); paraffin block punching, manual (D1 and D2) and with hand-press grommet inserting machine (D3 and D4).