Fig. 3

Two distinct histological patterns of the tumor are identified, with cholangiocytic differentiation (asterisks) identified in the top lesion (H&E, low power). Small uniform tumor “cancer stem cells” with small basophilic vesicular nuclei, occasional inconspicuous nucleoli, scant pale eosinophilic cytoplasm, indistinct cell borders, and frequent mitoses are seen throughout and are prominent at transitional zones (top inlay; H&E, high power). Tumor cells of similar cytology with more abundant eosinophilic cytoplasm surround an unpaired artery in the HCC-like areas (bottom inlay; H&E, intermediate power)