Skip to main content
Fig. 4 | Diagnostic Pathology

Fig. 4

From: Pediatric combined hepatocellular-cholangiocarcinoma (cHCC-CC) with neuroendocrine features: distinguishing genetic alterations detected by chromosomal microarray

Fig. 4

IHC panel. β-catenin (A) shows membranous but not nuclear staining, while alpha-fetoprotein (B) is negative; these findings are not supportive of hepatoblastoma. Negative Hep-Par1 (C), negative Glypican-3 (D), and largely non-canalicular staining pattern of pCEA (E) suggest poorly differentiated tumor if of hepatic origin. CK7 (F) and CK19 (G) show positive staining (strongly positive within the ductular components), highlighting cholangiolar-like differentiation. Focal areas of strongly positive chromogranin (H) and diffusely positive synaptophysin (I) highlight neuroendocrine-like differentiation

Back to article page

Diagnostic Pathology

ISSN: 1746-1596

Contact us