Fig. 3

Conventional-resolution vs super-resolution images of nucleus from HER2-positive and HER2-negative tissues. HER2 and CEP17 quantification and HER2 status evaluation in breast cancer tissue samples with dual-probe FISH for HER2 and CEP17 amplification, where red signals indicate HER2 and green signals indicate CEP17. Images show conventional-resolution of a single nucleus in (a) HER2-positive and (b) HER2-negative tissue, and super-resolution image of the nucleus of (c) HER2-positive and (d) HER2-negative tissue. The HER2 status was determined by routine FISH. The scale bar is 2 μm