Table 3 Morphological features of the human pulmonary dirofilariasis cases analyzed (PAS: Periodic Acid-Schiff). *For the immunohistochemistry, rabbit polyclonal antibody (ab905, Abcam) was applied
From: Emerging human pulmonary dirofilariasis in Hungary: a single center experience
Patient ID | Size (mm) | Grossing results | Histological features | Examination carried out to identify infectious origin | PCR result |
|---|---|---|---|---|---|
1 | 15 × 9 × 4 | Subpleural, well-circumscribed, yellow lesion | Necrotizing granulomatous reaction with thick, fibrotic capsule with central thrombosed pulmonary artery, containing helminth remnant. Lymphocytes, histiocytes, Langhans and foreign body-type giant cells in the surrounding areas. | Ziehl-Neelsen, PAS | Dirofilaria immitis |
2 | 21 × 15 × 15 | Subpleural, well-circumscribed, white lesion | Necrotizing granulomatous reaction with central helminth remnant. Foreign body type reaction, chronic inflammation, fibrosis. | Ziehl-Neelsen, PAS, Grocott | Dirofilaria immitis |
3 | 6 × 5 × 5 | Subpleural, well-circumscribed, yellow lesion | Necrotizing granulomatous reaction with central helminth remnant. Foreign body type reaction, chronic inflammation, fibrosis. | Ziehl-Neelsen, PAS | Dirofilaria immitis |
4 | 21 × 14 × 7 | Subpleural, well-circumscribed, white lesion | Necrotizing granulomatous reaction with central helminth remnant. Foreign body type reaction, calcification and granulation tissue formation. | Ziehl-Neelsen, PAS | Dirofilaria immitis |
5 | 18 × 11 × 6 | Subpleural, well-circumscribed, white lesion | Necrotizing granulomatous reaction with central helminth remnant. Foreign body type reaction, chronic inflammation, fibrosis. | Ziehl-Neelsen, PAS, Grocott, Mycobacterium tuberculosis* immunohistochemistry | Dirofilaria immitis |