Fig. 2

IHC score is correlated with CIN grade but not exactly corresponding. Eag1 staining corresponding Ki-67 and p16 stainings show positive predominantly found in the lower one-thirds of the epithelium (Score 1), which is most common in CIN1. Positive in the lower two-thirds of the epithelium (Score 2) is most common in CIN2. Positive in full-thickness of the epithelium (Score 2) is most common in CIN3+