Fig. 1

PSAT1 expression in HG-induced ARPE-19 cells. (A) Volcano plot shows differentially expressed genes in ARPE-19 cells induced by HG. (B) Heat map displaying the top 10 differentially expressed up- and down-regulated genes. (C) String Database Analysis of Protein-Protein Interaction Network (PPI) for top 100 Differentially Expressed Genes. (D) Ten candidate hub genes were identified from the PPI network using Cytoscape software utilizing the MCC algorithm of the plug-in CytoHubba