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Fig. 5 | Diagnostic Pathology

Fig. 5

From: PSAT1 is upregulated by METTL3 to attenuate high glucose-induced retinal pigment epithelial cell apoptosis and oxidative stress

Fig. 5

METTL3/PSAT1 regulated HG-mediated ARPE-19 cell viability and oxidative stress in vitro. (A and B) PSAT1 expression was determined in ARPE-19 cells transfected with sh-NC or sh-PSAT1 using RT-qPCR assay and Western blot assay. (C-F) ARPE-19 cells were treated with NG, HG, HG + sh-PSAT1, or HG + sh-PSAT1 + sh-PSAT1. (C) CCK-8 analysis of cell viability in treated ARPE-19. (D-F) Commercial kits were applied to analyze ROS, MDA, and GSH-Px levels in treated ARPE-19 cells. *P < 0.05, **P < 0.01, ***P < 0.001, n = 3

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Diagnostic Pathology

ISSN: 1746-1596

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