Fig. 6

METTL3 relieved HG-induced ARPE-19 cell apoptosis via regulating PSAT1. ARPE-19 cells were treated with NG, HG, HG + sh-PSAT1, or HG + sh-PSAT1 + sh-PSAT1. (A) TUNEL analysis of cell apoptosis in treated ARPE-19 cells. (B) Western blot assay was used to determine Bcl-2 and Bax protein levels in treated ARPE-19 cells. *P < 0.05, **P < 0.01, ***P < 0.001, n = 3