Table 4 Relationship between BRAF/RET/TERT genes and clinicopathological characteristics of PTC patients in different studies

BRAF

This study

855

tumor diameter, histological subtypes

Li C et al. [16]

6372

lymphatic metastasis, TNM staging, extrathyroidal extension, tumor diameter, male, multifocal presentation, tumor capsule, classic of PTC, and tall-cell variant of PTC

Chung JH et al. [17]

8315

extrathyroidal extension, lymphatic metastasis, TNM staging

Wei X et al. [18]

9908

age, male, multifocal presentation, lymphatic metastasis, extrathyroidal extension, TNM staging

Xing M et al. [19]

219

extrathyroidal extension, lymphatic metastasis, TNM staging

Scheffel RS et al. [20]

134

This paper is based on single center data, and they did not identify any meaningful pathological parameters

Xing M et al. [21]

507

male, tumor diameter, extrathyroidal extension, lymphatic metastasis, TNM staging

RET

This study

855

tumor diameter, lymphatic metastasis

Khan et al. [27]

48

gender, TSH level, lymphatic metastasis

Huang et al. [28]

108

lymphatic metastasis, the immune microenvironment

Scholfield et al. [29]

41

aggressive histopathological features, later T stages

TERT

This study

855

gender, tumor diameter, extrathyroidal extension, TNM staging

Liu’s et al. [33]

408

age, tumor diameter, extrathyroidal extension, PTC advanced stages III/IV

Zhao L et al. [34]

8338

lymphatic metastasis, extrathyroidal extension, PTC advanced stages III/IV

Sang Y et al. [35]

382

age, extrathyroidal extension, lymphatic metastasis, PTC advanced stages III/IV

Li M et al. [36]

143

age, PTC advanced stages III/IV