Fig. 3

Horizontal and longitudinal comparisons of the proportion of HER2 genetic heterogeneity, average HER2 signal/cell ratio, and HER2/CEP17 ratio reported by 115 laboratories that submitted interpretations for both case 1–5 and case 2–5. (a) Distribution of the proportion of HER2 genetic heterogeneity of case 1–5 and case 2–5 reported by 115 laboratories that submitted interpretations. (b) Distribution of the average HER2 signals/cells of the nonamplified areas of case 1–5 and case 2–5 reported by 115 laboratories that submitted interpretations. (c) The distributions of the HER2/CEP17 ratios of the nonamplified areas of case 1–5 and case 2–5 reported by 115 laboratories that submitted interpretations