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Fig. 1 | Diagnostic Pathology

Fig. 1

From: Advanced NGS analysis of cell-free tumor DNA supports clonal relation to primary high-grade B-cell lymphoma lesion and CNS relapse despite MRI negativity

Fig. 1

Outputs from standard and supplemental examination of a patient with aggressive lymphoma infiltrating the CNS (except histology that could not be performed): (A) morphology of BM infiltrated with lymphoma cells (Burkitt lymphoma-like phenotype); (B) flow cytometric analysis showing clonal infiltration of BM and CSF (malignant lymphoma cells in red, non-B cells in blue); (C) timeline of various therapy administrations and laboratory examinations (time corresponds with sampling, asterisk marks test performed retrospectively). BM– bone marrow, CNS– central nervous system, CSF– cerebrospinal fluid, CT– computed tomography, FC– flow cytometry, NGS– next-generation sequencing; and (D) cytogenetic results of diagnostic BM examination showing complex karyotype by mFISH on the left (47,XY,t(4;9)(q?31.2;p?21),+8,t(8;22)(q24;q11),t(9;13)(p?13;q?14.3),dup(12)(q?q?), der(14)t(14;18)(q32;q21), and IGL and BCL2 rearrangements by FISH on the right (arrows mark chromosomal disruptions).

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Diagnostic Pathology

ISSN: 1746-1596

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