Fig. 2

Somatic mutations and copy numbers of the low-grade oncocytic tumor (LOT). A: The wild-type forkhead box I 1 (FOXI1) protein and the predicted mutant FOXI1 harboring the mutation identified in the LOT in this study. Three-dimensional structures shown on bottom were drawn by AlphaFold2. The circle (dotted line) indicates the DNA binding domain, which was drawn as a highly confident area by AlphaFold2 (blue ribbons). The DNA binding region of the mutant FOXI1 showed a similar structure as that of wild-type FOXI1. B: Wild-type keratin 6c (KRT6C) protein and the predicted mutant KRT6C in the LOT. Three-dimensional structures shown on bottom were drawn by AlphaFold2. Three coils, coli 1 A, coil 1B and coil 2, of KRT6C were drawn as a highly confident area by AlphaFold2 (blue ribbons). The location and structure of the three coils in the mutant KRT6C were similar to those of wild-type KRT6C. C: Copy number alteration in the LOT compared with the nontumor kidney surrounding the LOT. Black bar in the figure indicates the mean copy number of each chromosome. No copy number alteration was detected on each chromosome