Whole exome sequencing identified mutations of forkhead box I 1 (FOXI1), keratin 6 C (KRT6C) and gap junction protein delta 2 (GJD2) in a low-grade oncocytic tumor of the kidney: a case report

Table 1 Mutations in the low-grade oncocytic tumor (LOT)

position	gene	mutation of LOT	VAF of LOT	read depth LOT/Nontumor	predicted change of protein	annotation Impact	SIFT prediction	FATHMM prediction	PROVEAN prediction	MetaSVM prediction
chr5: 17,010,647	FOXI1	c. 517 C > A	43.4	366/324	p.H173N	Moderate	D	D	D	D
ch12: 52,471,296	KRT6C	c. 913 G > C	38.6	498/420	p.E305Q	Moderate	D	D	D	D
chr15: 34,752,927	GJD2	c.517 G > T	28.3	187/164	p.E173*	High

D: Damaging; FOXI1: forkhead box I 1; GJD2: gap junction protein delta 2; KRT6C: keratin 6 C; LOT: low-grade oncocytic tumor; VAF: variant allele frequency

ISSN: 1746-1596