Fig. 2
From: Trichorhinophalangeal syndrome type 1 (TRPS1) in breast pathology: diagnostic utility and pitfalls
Metaplastic primary breast carcinoma with TPRS1, GATA3 and SOX10 immunostains. 2A: Hematoxylin and eosin (H & E)-stained section at 50X magnification showing poorly differentiated carcinoma with matrix-producing stroma consistent with metaplastic breast carcinoma. 2B: H & E-stained section at 100x showing tumor cells with matrix-producing stroma in the background. 2C: TRPS1 immunostaining at 50X magnification depicting strong diffuse nuclear positivity in tumor cells. 2D: GATA3 immunostaining revealing negative nuclear expression. Background cytoplasmic staining is seen in stroma. 2E: SOX10 immunostaining at same magnification showing patching moderate nuclear staining in tumor cells