Table 2 Inter-reader agreement for central pathologists with HER2-low training
HER2 IHC score cutoff | OPA, % (95% CI) | Fleiss’ kappa | ||
|---|---|---|---|---|
Pathologists 1 vs. 2 | Pathologists 2 vs. 3 | Pathologists 1 vs. 3 | ||
0 absent membrane staininga, b vs. 0 with membrane staininga 1+, 2+, 3+ | 96 (93–97) | 96 (94–98) | 97 (95–99) | 0.68 |
0c vs. 1+, 2+, 3+ | 94 (92–96) | 94 (92–96) | 91 (88–94) | 0.79 |
0, 1 + vs. 2+, 3+ | 85 (81–88) | 85 (81–88) | 94 (90–95) | 0.74 |
0, 1+, 2 + vs. 3+ | 97 (95–98) | 87 (84–90) | 87 (84–90) | 0.67 |