Table 1 Clinicopathological features of wide-type gists with NTRK fusions
Reference | Sex/Age (year) | Tumors site | Size (cm) | KIT/PDGFRA/RAS-P/SDH mutations | IHC (pan-TRK) | NGS | FISH | Surgery | Drug treatment | Progress or relapse/Time (month) | Death/Time (month) |
|---|---|---|---|---|---|---|---|---|---|---|---|
Machado I [21] | F/57 | Pelvic | 27 | -/-/-/- | + focal | ETV6::NTRK3 | NTRK3 | Yes | Entrectinib | Yes/1 | No/3 |
Shi E [8] | M/55 | Small intestine | NA | -/-/-/- | NA | ETV6::NTRK3 | NA | No | Sunitinib Sorafenib Nilotinib Regorafenib Larotrectinib | No/4 | No/4 |
M/54 | Colon | NA | -/-/-/- | NA | ETV6::NTRK3 | NA | No | Imatinib Sunitinib Sorafenib Linsitinib | Yes/NA | No/12 | |
Castillon M [37] | M/59 | NA | NA | -/-/NA/NA | - | NA | ETV6::NTRK3 | No | No | Yes/NA | Yes/NA |
Dufresne A [15] | F/74 | Duodenal | 8 | -/-/-/- | NA | RBPMS::NTRK3 | NA | Yes | Imatinib Sunitinib Cabozantinib | Yes/5 | Yes/NA |
Lee JH [38] | F/44 | Rectum | 2.8 | -/-/NA/NA | Among 5 NTRK-fusion cases, only one was positive | No | NTRK1 | Yes | No | Yes/108 | Yes/132 |
M/45 | Duodenum | 1.7 | -/-/NA/NA | No | NTRK3 | Yes | No | No/72 | No/72 | ||
F/65 | Stomach | 17 | -/-/NA/NA | No | NTRK1 | Yes | Imatinib | Yes/26 | Yes/96 | ||
F/61 | Jejunum | 3.9 | -/-/NA/NA | No | NTRK1 | Yes | Imatinib | No/48 | No/48 | ||
M/43 | Rectum | 11 | -/-/NA/NA | NTRK3 | NTRK3 | Yes | No | No/36 | No/36 | ||
Zhang H [39] | M/66 | Stomach | 12 | -/-/NA/NA | + | No | NTRK3 | Yes | No TRKi | No/112 | No/112 |
M/47 | Duodenum | 5 | -/-/NA/NA | + | No | NTRK3 | Yes | No TRKi | No/78 | No/78 | |
F/34 | Stomach | NA | -/-/NA/NA | + | No | NTRK3 | Yes | No TRKi | No/123 | No/123 | |
Brenca M [40] | M/44 | Rectum | 5 | -/-/-/- | NA | ETV6::NTRK3 | ETV6 | Yes | No | No/44 | No/44 |
D’Alpino Peixoto R [16] | M/20 | Rectum | 7 | -/-/NA/NA | NA | LMNA::NTRK1 | NA | Yes | No | NA/NA | NA/NA |
Cao Z [24] | F/52 | Mesentery | 10 | -/-/-/- | + | ETV6::NTRK3 | ETV6::NTRK3 | Yes | No | Yes/11 | Yes/11 |
M/56 | Stomach | 16 | -/-/-/- | - | ETV6::NTRK3 | ETV6::NTRK3 | Yes | Imatinib | No/58 | No/58 | |
this study | M/66 | Jejunum | 3.8 | -/-/-/- | - | CDC42BPB:: NTRK3 | NTRK3 | Yes | No | No/15 | No/15 |