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Table 3 Multivariate analysis of variables related to RAI-refractory DTC based on binary logistic regression analysis

From: The ability of anexelekto (AXL) expression and TERT promoter mutation to predict radioiodine-refractory differentiated thyroid carcinoma

Variable

Adjusted OR (95% CI)

p value

Aggressive subtype

Aggressive

74.75 (1.31–4266.20)

0.037*

Nonaggressive

1 (ref)

 

TNM staging

II-IV

8.05 (0.60–108.09)

0.116

I

1 (ref)

 

LVI

Yes

2.69 (0.43–16.96)

0.291

No

1 (ref)

 

m-ETE

Yes

5.44 (0.92–32.07)

0.061

No

1 (ref)

 

AXL expression

> 10% (high)

44.98 (1.41–1439.03)

0.031*

0–10% (negative/low)

1 (ref)

 

TERT promoter

Mutation

10.95 (1.06–112.92)

0.044*

Wild-type

1 (ref)

 
  1. DTC, differentiated thyroid carcinoma; RAI, radioactive iodine; OR, odds ratio; CI, confidence interval; LVI, lymphovascular invasion; m-ETE, microscopic extrathyroid extension; AXL, anexelekto; TERT, telomerase reverse transcriptase; ref, reference
  2. *Statistically significant difference