Fig. 3

Overall survival according to B7-H3 expression in MB. (A) MB patients (n = 41) were categorized into two groups according to B7-H3 expression levels: low/moderate and high. OS probabilities were estimated using the Kaplan-Meier method, and survival distributions were compared via the log-rank test (χ² = 6.791, df = 1, p = 0.009). High B7-H3 expression was significantly associated with shorter OS. The median survival time for patients with high B7-H3 expression was 83.7 months (95% CI: 3.9-163.5), whereas the median survival time for patients with low/moderate B7-H3 expression was not reached during the follow-up period. (B) Patients were further stratified based on B7-H3 cellular localization (cytoplasm only vs. cytoplasmic/membranous expression). In the two subgroups, high B7-H3 expression was associated with lower survival probabilities. However, a significant association with a worse OS was observed only in patients with cytoplasmic/membranous B7-H3 expression (log-rank test: χ² = 4.046, df = 1, p = 0.044)