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Table 2 Clinicopathological features of patients with MSI-H and CNL subtypes

From: Molecular subtyping of endometrial cancer via a simplified one-step NGS classifier, ARID1A and ZFHX4 mutations help further subclassify CNL/MSI-H patients

Items/N (%)

All patients in MSI-H and CNL subtypes (N = 187)

Patients with comprehensive genetic testing in MSI-H and CNL subtypes (N = 39)

p value

Subtype

  

0.45

 CNL

143 (76.47%)

27 (69.23%)

 

 MSI-H

44 (23.53%)

12 (30.77%)

 

Age (number)

  

0.24

 Mean ± SD

54.25 ± 9.51

56.54 ± 8.86

 

 Median [min-max]

54.00 [31.00, 76.00]

59.00 [31.00, 75.00]

 

Stage

  

0.21

 I

129 (68.98%)

28 (71.79%)

 

 II

14 (7.49%)

1 (2.56%)

 

 III

24 (12.83%)

9 (23.08%)

 

 IV

2 (1.07%)

0 (0.00%)

 

 Unknow

18 (9.63%)

1 (2.56%)

 

LVSI

  

0.08

 Yes

6 (3.21%)

3 (7.69%)

 

 No

142 (75.94%)

33 (84.62%)

 

 Unknown

39 (20.86%)

3 (7.69%)

 

Histology Subtype

  

0.11

 Endometrioid

153 (81.82%)

38 (97.44%)

 

 Serous

3 (1.60%)

1 (2.56%)

 

 others

5 (2.67%)

0 (0.00%)

 

 Unknown

26 (13.90%)

0 (0.00%)

 

Grade

  

< 0.01

 G1

84 (44.92%)

10 (25.64%)

 

 G2

48 (25.67%)

16 (41.03%)

 

 G3

25 (13.37%)

12 (30.77%)

 

 Undifferentiated

2 (1.07%)

1 (2.56%)

 

 Unknown

28 (14.97%)

0 (0.00%)

 

OS

  

0.75

 Mean ± SD

66.18 ± 24.35

75.21 ± 31.23

 

 Median [min-max]

67.00 [7.00, 122.00]

74.00 [7.00, 121.00]

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