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Table 1 Clinical data of 35 patients with lymphoma complicated with primary solid tumor

From: Clinical analysis of lymphoma with malignant solid tumor simultaneously: a retrospective case series

No.

Sex/

age

Lymphoma

 

Solid tumor

1st Tumor

Survival Status

Follow-up (month)

Subtypes

site

Treatment

 

Subtypes

site

Treatment

1

M/49

MALT

Parotid gland

RT

 

Papillary carcinoma

Thyroid

Surgery

Lymphoma

Survival

38

2

M/69

SLL/CLL

Lymph node

No treatment

 

Clear cell carcinoma

Kidney

Surgery and Axitinib

Lymphoma

Survival

34

3

F/59

DLBCL

Sinuses

RCDOP, RCHOP, RTX, MTX, and autoHSCT

 

Papillary carcinoma

Thyroid

Levothyroxine sodium

Lymphoma

Survival

33

4

M/76

DLBCL

Abdominal cavity

No treatment

 

Adenocarcinoma

rectum

No treatment

Solid tumor

Death

3

5

F/66

DLBCL

Pelvic cavity

RCHOP and RCDOP

 

Papillary carcinoma

Thyroid

NA

Lymphoma

NA

NA

6

F/55

DLBCL

Lymph node

RCHOP, RCDOP and RGDP

 

Papillary carcinoma

Thyroid

Surgery

Solid tumor

NA

NA

7

M/74

DLBCL

Small intestine

Refusal of treatment

 

Adenocarcinoma

Stomach

Surgery

Lymphoma

Death

6

8

F/81

DLBCL

Pharynx

RminiCHOP and RminiCDOP

 

Papillary carcinoma

Thyroid

No treatment

Lymphoma

Survival

28

9

F/70

MALT

Breast

Mammotome excision

 

Invasive ductal carcinoma

Breast

Surgery, EPI, CTX, DTX and RT

Lymphoma

Survival

27

10

M/80

PTCL

Skin

miniCVP and miniCHOP

 

Adenocarcinoma

Prostate

Endocrine therapy

Lymphoma

Survival

27

11

M/70

MZL

Lymph node

RCDOP, CVP and Obrutinib

 

Adenocarcinoma

Prostate

Endocrine therapy

Lymphoma

Survival

27

12

M/62

SLL/CLL

Appendix

Surgery and Ibrutinib

 

Adenocarcinoma

Lung

Surgery

Solid tumor

Survival

26

13

F/72

FL

tonsil

RCHOP

 

Adenocarcinoma

Lung

Surgery

Lymphoma

Survival

24

14

M/74

SLL/CLL

Abdominal cavity

No treatment

 

Adenocarcinoma

Colon

Surgery

Solid tumor

Survival

23

15

F/67

DLBCL

Stomach

RCDOP

 

Papillary carcinoma

Thyroid

No treatment

Lymphoma

Survival

19

16

F/83

DLBCL

Stomach

R-miniCDOP, R2-GemOx and BR

 

Adenocarcinoma

Rectum

No treatment

Lymphoma

Death

6

17

M/57

FL

Lymph node

RCHOP

 

Squamous cell carcinoma

Lung

Microwave ablation

Lymphoma

Survival

17

18

F/55

SLL/CLL

Lymph node

Ibrutinib and RTX

 

Micropapillary carcinoma

Thyroid

Surgery

Lymphoma

Survival

68

19

M/68

PTCL

Small intestine

CHOP

 

Papillary urothelial carcinoma

Bladder

Transurethral resection of bladder tumors

Solid tumor

NA

NA

20

M/75

DLBCL

Lymph node

R2-GemOx

 

Adenocarcinoma

Colon

No treatment

Solid tumor

Death

1

21

F/55

MALT

Stomach

RT and RCVP

 

Papillary carcinoma

Thyroid

Surgery

Lymphoma

Survival

56

22

M/65

DLBCL

Stomach

miniCHOP and RCHOP

 

Adenocarcinoma

appendix

Surgery

Solid tumor

Death

6

23

M/80

SLL/CLL

Lymph node

No treatment

 

Adenocarcinoma

Stomach

Surgery

Lymphoma

NA

NA

24

M/72

SLL/CLL

Lymph node

No treatment

 

Adenocarcinoma

Lung

Cisplatin and Pemetrexed

Lymphoma

Death

20

25

M/68

MZL

Lymph node

No treatment

 

Adenocarcinoma

Stomach

Surgery and SOX

Lymphoma

Survival

41

26

M/62

MZL

Lymph node

NA

 

Squamous cell carcinoma

Pharynx

Surgery, RT and chemotherapy

Lymphoma

NA

NA

27

M/71

DLBCL

Ileocecal

RCHOP

 

Adenocarcinoma

Colon

No treatment

Lymphoma

Survival

16

28

M/59

DLBCL

Lymph node

RCHOP and PD1 + RICE

 

Adenocarcinoma

Stomach

Surgery

Lymphoma

Survival

15

29

M/62

DLBCL

Tonsil

RCDOP

 

Adenocarcinoma

Stomach

Surgery

Solid tumor

Survival

14

30

M/79

SLL/CLL

Rectum

Surgery

 

Adenocarcinoma

Rectum

Surgery

lymphoma

Survival

14

31

F/66

SLL/CLL

Lymph node

No treatment

 

Adenocarcinoma

Lung

Targeted therapy

Solid tumor

Survival

7

32

M/59

PTCL

Lymph node

Chemotherapy

 

NA

Lung

Surgery

lymphoma

Survival

10

33

M/65

WM

bone marrow

Obrutinib

 

Adenocarcinoma

Colon

Surgery

Solid tumor

Survival

7

34

F/67

MZBL

Lymph node

BR

 

Papillary carcinoma

Thyroid

No treatment

Lymphoma

Survival

1

35

F /65

DLBCL

Lymph node

RCHOP

 

Adenocarcinoma

Lung

No treatment

lymphoma

Survival

0

  1. Abbreviation: MALT: marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue; SLL/CLL: small lymphocytic lymphoma/chronic lymphocytic leukemia; DLBCL: diffuse large B-cell lymphoma; PTCL: peripheral T-cell lymphoma; MZL: marginal zone lymphoma; FL: follicular lymphoma; WM: Waldenström macroglobulinemia; RT: Radiotherapy; RCDOP: rituximab + cyclophosphamide + vincristine + liposomal doxorubicin + prednisone; RCHOP: rituximab + cyclophosphamide + vincristine + doxorubicin + prednisone; auto-HSCT: autologous hematopoietic stem cell transplantation; R2-GemOx: rituximab + lenalidomide + gemcitabine + oxaliplatin; BR: rituximab + bendamustine; RCVP: rituximab + cyclophosphamide + vindesine + dexamethasone; RGDP: rituximab + gemcitabine + cisplatin + dexamethasone; SOX: oxaliplatin + tegafur; MTX: methotrexate; RTX: rituximab; CTX: cyclophosphamide; DTX: docetaxel; EPI: epirubicin; RICE: rituximab + ifosfamide + carboplatin + etoposide; NA, not available