Fig. 1

Morphological comparison between mutant group and wild-type group. Representative images of Retiform differentiation (A, E), Cords or ribbon-like (B, F), Mucinous edematous stroma (C, G) and Hemorrhage (D, H). Mutant group exhibits more retiform differentiation (A), cords or ribbon-like arrangement (B), obvious mucinous edematous stroma (C) and hemorrhage (D). In contrast, wild-type group rarely exhibits retiform differentiation (E), cords or ribbon-like arrangement (F), mucinous edematous stroma (G) and hemorrhage (H)