Fig. 3

ACSL4 expression in normal pancreatic ducts, low-grade PanIN, IPMA, invasive PDAC, noninvasive IPMC, and invasive IPMC. ACSL4 expression was significantly higher in malignant lesions compared to benign lesions (A). ACSL4 expression was significantly higher in invasive PDAC than in low-grade PanIN and normal pancreatic duct (P < 0.001, respectively). ACSL4 expression was significantly higher in invasive IPMC than in IPMA (P < 0.001). ACSL4 expression was significantly higher in noninvasive IPMC than in IPMA (P < 0.001). ACSL4 expression was higher in cases of well or moderately differentiated tumors compared to those of poorly differentiated tumors (B, P = 0.024)